About AKBA and its benefits

AKBA (acetyl-11-keto-beta-boswellic acid) is a key active compound derived from the gum resin of Boswellia Serrata, also known as Indian Frankincense. It is known for its potential anti-cancer properties attributed to how it affects genes associated with cancer development and progression. It is believed to work by inhibiting certain enzymes and signaling pathways that contribute to inflammation and cancer cell growth. However, AKBA has poor solubility in water, which can limit its absorption and utilization by the body.

To enhance the bioavailability of AKBA, Sunflower Lecithin and Piperine are added to supplements. Sunflower Lecithin is a natural emulsifier that helps increase the absorption of fat-soluble compounds like AKBA. Piperine, a compound found in black pepper, can enhance the bioavailability of many nutrients, including AKBA, by inhibiting certain enzymes in the liver and intestines that break down and eliminate these compounds from the body.

Overall, AKBA, Sunflower Lecithin, and Piperine are natural ingredients that have the potential to offer various health benefits, including anti-cancer properties and enhanced absorption of nutrients.

Potential benefits of AKBA LPX, especially on cancer, supported by research studies:​

1. Anti-cancer properties: AKBA has been found to have anti-cancer properties by affecting genes associated with cancer development and progression. Several studies have demonstrated the effectiveness of AKBA against various types of cancer, including breast, prostate, colon, pancreatic, and bladder cancer. (Reference: Siddiqui MZ. Boswellia serrata, a potential anti-inflammatory agent: an overview. Indian J Pharm Sci. 2011;73(3):255-261.)

2. Anti-inflammatory properties: AKBA has potent anti-inflammatory effects that may help to reduce inflammation associated with cancer. In one study, AKBA was found to inhibit the production of inflammatory molecules such as TNF-α and IL-1β. (Reference: Park YS, Lee JH, Bondar J, et al. Cytotoxic action of acetyl-11-keto-beta-boswellic acid (AKBA) on meningioma cells. Planta Med. 2002;68(5):397-401.)

3. Joint pain relief: AKBA has been found to be effective in reducing joint pain and inflammation associated with osteoarthritis. A study found that AKBA was able to reduce joint pain and increase mobility in patients with osteoarthritis. (Reference: Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010;7(6):366-377.)

4. Cardiovascular health: AKBA may also have beneficial effects on cardiovascular health. A study found that AKBA was able to reduce the levels of LDL cholesterol and triglycerides in the blood, while increasing the levels of HDL cholesterol. (Reference: Syrovets T, Buchele B, Gedig E, et al. Acetyl-boswellic acids are novel lipooxygenase inhibitors, but do not interfere with the catalytic activity of the enzyme. J Lipid Res. 1998;39(11): 2289-2295.)

5. Immune system support: AKBA may have immune-boosting effects that can support overall health. A study found that AKBA was able to increase the production of white blood cells in the body, which play a key role in immune system function. (Reference: Singh S, Khajuria A, Taneja SC, et al. The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats. Phytomedicine. 2008;15(6-7):408-415.)